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TOXICITY OF ORAL STEROIDS

 

That the 17-alpha alkylated steroids are toxic to the liver, is indisputable fact. Surely anyone who has met the steroids, I heard rules like: "There is no need to take more than 50 mg of oxymetholone per day and no more than 4 weeks ...". However, they are similar to the arguments based on truth? On the Internet we can find a lot of studies that confirm this assumption, but also refuted. Let's look at some of them a little closer ...

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If you simply place the vial injecting drunk with testosterone (or some derivative thereof) will be ineffective, because they first pass metabolism will be very effective Uptake and degraded. In order for you to make effective oral steroid form only a small interference in the molecule - bind to steroid string some strong bond that can not be easily removed by liver enzymes. In this way producing the steroid that is effective in the oral form. This adjustment is done mostly at the 17-carbon (used as the first carbon. Methenolone - Primobolan). Editing but it also has one disadvantage: this steroid resistant to degradation becomes toxic to the liver ...

According to one study, which examined 131 cases of death from hepatic angiosarcoma (a type of liver cancer), 3.1% of these people had a history of anabolic androgenic steroids, which suggests that these steroids can give rise to malignant tumors of the liver. However, this study does not provide any evidence that it is the steroids were the cause of cancer. Let us remember that if we took 100 random people and see how many of them ever having used anabolic steroids (including when they were steroid-imposed medical treatment in order) the number would be very close to 3 percent. Moreover, there is no study that would prove that some 70's, the number of deaths rose to hepatic angiosarcoma, while over the same period has risen many times users of anabolic steroids.


Another interesting study 2 describes the formation of multiple adenomas of the liver (small and relatively small number of harmless cysts) in Japanese girl after oxymetholone use in the treatment of aplastic anemia. This could theoretically for those who used oxymetholone mean that they would rather look for something else, but when you look at the study a little more closely, we discover an interesting thing: the girl was diagnosed with aplastic anemia at age 14 and the first changes in the liver were observed after six years of use Oxymetholone 30mg daily! Weighing girls somewhere around 45 kg to a dose of approximately 60 to 80 mg for an adult male - bodybuilder day for 6 years! Compare this with the statement in the first paragraph of this article!


Another study 3 describes the toxicity of various steroids on cell culture of rat liver cells. The following concentrations were used: 1 × 10-8M, 1 x 10-6M, 1 × 10-4M. Several factors were examined cell damage. To change the parameters were only at 17-alkylated steroids, methyltestosterone, stanozolol and oxymetholone and only at a concentration of 1 × 10-4 (which is based on the equivalent steroid dose of 30-40mg per kg). This study reveals two things:


1. Alpha alkylated steroids are hepatotoxic, but only at very high doses.


2. Non alkylated steroids do not have very high concentrations of hepatotoxic effects.


Study 4 examined the effect of 8-week cycle of fluoxymesterone, methylandrostenolone and stanozolol to rats at a dose of 10mg/kg week. For 100-pound man to a dose of 1000 mg weekly (143 mg daily). Half of the rats were exposed to physical strain and half not. They were identified as activity of certain enzymes in the liver cells, but serum (blood) levels of liver enzymes in both groups were in the standard! This means that the dose of 17-alpha alkylated steroids while changing conditions in the activity of some enzymes, but in any case we can not speak of hepatotoxicity in the true sense of the word!


What follows from all this? It is true that the 17-alpha alkylated steroids are hepatotoxic. But it is also true that only in extremely high doses. 5.6 According to other studies, the levels of liver enzymes return to standard within 3 months after planting. And also elevated levels of these enzymes in the cycle may be the source of hard training and not on steroids. Probably hysteria about hazards of these substances is just one of the other myths, which is in this sport more than enough.


This article is for informational purposes only! By this or any other article is not conducive to the use of any prohibited substances, and does not support a potential health problems caused by the use of such substances.