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ACE-031 is an inhibitor of myostatin (GDF-8 - a substance that slows down and reduces the growth of muscle mass). ACE-031 ostatin supports a faster, more robust and better growth of new muscle mass.
Myostatin (GDF-8 = Growth Differentiation Factor 8 = Growth differentiation factor 8) is a protein which in humans is encoded MSTN gene. Myostatin (GDF-8) belongs to a group GDF proteins that inhibit the growth of muscle tissue. Myostatin protein is produced mainly skeletal muscle cells, circulating in the blood and acts on muscle tissue - slows the development of stem cells (inhibits formation of new muscle mass). The exact process remains the still unknown.
Myostatin and its related gene was discovered in 1997. Doctors Genetics Se-Jin Lee and Alexander McPherron discovered that the cause of abnormal and extra-massive muscularity cattle breeds Belgian Blue and Piedmontese are defective myostatin genes (such massive muscles are called the English term "Double muscling ").
Unnaturally mutated mice so that they have little myostatin. The result was that the mutant mice had approx. twice as much as normal mouse muscle. These mice were subsequently named as "mighty mouse" (Mighty mice). Mutations in myostatin gene-u causes the body is unable to produce myostatin, and it then subsequently hampered by muscle growth.
These mutations began then use to breed new, more muscular breeds. Genetic mutations of the myostatin-u were also observed in race racing greyhound dogs closely related (Whippet). Individuals with mutations in the myostatin gene were far better runners and were characterized also by another physique. It is undisputed that animals lacking myostatin or animals doped substances that block the activity of myostatin (such as. Follistatin) have considerably bigger muscles. Even a 20 percent reduction in the level of myostatin has potentially great influence on massive muscle development.
In 2004, at the German boy identified mutation of both copies of the myostatin gene. That makes it much stronger than its peers. The boy is growing and becoming more forcefully exceeds their peers. The lack of myostatin is still not signed on his health. Doctors thereto will hereinafter watch case that somehow began to increase significantly its vital organs (e.g. heart His). His mother, a former sprinter, while a mutation in only one copy of the gene. People with mutations in both copies of MSTN gene in each cell (homozygotes) leads to a much greater increase in muscle mass and strength than the ordinary people, and therefore are much stronger than usual. People with mutations in one copy MSTN gene in each cell is also increased muscle mass and strength, but to a lesser extent.
In 2013, the company Acceleron Pharma published results of human studies in which it was sampled 48 healthy women aged 45-75 years old submitted to only one injection containing 0.02, 0.05, 0.1, 0.3, 1 or 3 mg of ACE-031 per 1 kg of body weight. Dose 3 mg / kg resulted in them to increase muscle volume by 5 percent, the total muscle mass was increased by 3 percent, while it seemed that they also reduce the quantity of body fat. Injection ACE-031 reduces the concentration of leptin. This supports the assumption that the ACE-031 actively reduces the level of fat. ACE-031 remained in the body after administration in circulation for several weeks, the half-life was set at 10 to 15 days.
Inhibition of myostatin-in leads to muscle hyperplasia (growth of new muscle fibers) and substantially greater hypertrophy (growth and increase the existing muscle fibers). For this reason, these products for athletes seeking to increase muscle mass and strength in the future truly great potential.
One of the best bodybuilders ever - phenomenal Flex Wheeler was reportedly also a lack of myostatin-u.
Effects of ACE-031:
ACE-031 causes a massive increase in muscle mass and strength, which reportedly exceeds even the most efficient volume hardcore steroids such. Oxymetholone.
The use of ACE-031 is rapid, almost immediate increase in muscle hardness.
ACE-031 promotes fat burning.
Even the small amount of the ACE-031 1 mg can have a significant effect. Athletes who received 1 mg dose of ACE-031 1x per week for 3-4 weeks, talking about almost immediate increase in hardness, a rapid increase muscle mass and strength at a level that surpassed even the hardcore volume anabolic-androgen steroid Oxymetholone!
The second possible way to use it is to start with a dose of 200 mcg ACE-031 daily, every other week dose of 100 mcg increase with the length of treatment should be as 3-4 weeks.
After the treatments should be a pause in the use of ACE-031 for at least 14 days.
Keep in mind that ACE-031 is a very fragile material! Should be administered separately, since the addition of other peptides (in common syringe) may be damaged. Even with a bottle of diluted ACE-031 you should not shake, and only the very steep antibacterial solution is injected into the vial ACE-031 can cause damage to the peptides in the upper layers of powder.
Possible side effects:
In clinical studies, which did f. Acceleron Pharma sample of adult males (volunteers), was observed in the treatment with ACE-031 some participants minor nosebleeds, bleeding gums, or small dilated blood vessels in the skin. Most of these side effects, however, has completely disappeared after discontinuation of therapy and discontinuation of ACE-031st
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Product name: Modified GRF 1-29 - 2mg Substance: Peptide Manufacturer: Magnus...