Enurace is suitable for the treatment of urinary incontinence in female dogs that are sterilized and whose ovaries and uterus are removed. The urinary incontinence is caused by low pressure in the circular muscles that close the urethra. Enurace is not suitable for the treatment of unwanted urination due to behavioral problems and may only be administered orally.
Let’s start with ephedrine’s basic mechanism of action. Ephedrine is a sympathomimetic, which means it acts to increase sympathetic activity. Why is this important? Because there is a drop in sympathetic activity when you cut calories. When you get a drop in sympathetic activity you get a decrease in metabolic rate and lower rates of lipolysis (fat mobilization). This can play a significant role in why you plateau on long-term diets. The use of ephedrine and caffeine can stave off this drop in metabolic rate and allow fat loss to continue unabated for several additional weeks.
People often want to compare ephedrine to Clenbuterol. This is fine as long as you realize that they act in different ways. Clenbuterol is a specific beta-2 adrenergic agonist. As such, Clenbuterol interacts directly with beta-2 receptors on muscle and fat tissue. Ephedrine, on the other hand, is not a direct beta-2 agonist. In fact, ephedrine is a poor ligand for the beta-2 receptor. Instead, ephedrine stimulates the release of noradrenaline from sympathetic nerve terminals. The noradrenaline then goes on to interact with muscle and fat cells as a nonspecific adrenergic agonist. This simply means that noradrenaline activates beta-2 receptors, but also other beta-receptors as well as alpha-receptors. So to compare ephedrine and Clenbuterol you must take into account their differences.
The differences between ephedrine and Clenbuterol are important. For example, Clenbuterol is a very potent beta-2 agonist. As a result, within 14 to 21 days, the beta-2 receptors on muscle and fat cells will be drawn into the cell membrane to reduce their availability to Clenbuterol. Then, if you continue to take it, they will be disassembled all together, leaving you insensitive to Clenbuterol. It then takes at least 2-3 weeks for receptors to replenish themselves on muscle and fat cells. Once again, ephedrine is different with respect to down regulation. Ephedrine, being a much weaker agonist, does not cause rapid desensitization and/or down-regulation of adrenergic receptors. This allows ephedrine to be used effectively for many months. Despite these differences, both drugs should be tapered over the course of several weeks before discontinuing them. If you don’t, you will quickly replace the fat you just lost due to an increased appetite and a decreased ability of fat cells to mobilize stored fat.
Your diet will also make a difference in what effects ephedrine will produce. Insulin prevents lipolysis. Insulin has been shown to inhibit lipolysis in a phosphatidylinositol 3-kinase- (PI3K) and phosphodiesterase 3B (PDE3)-dependent manner and to stimulate fractional re-esterification of free fatty acids (FFAs), resulting in inhibition of FFA release (1,2). Even in the presence of ephedrine and/or noradrenaline, a high carbohydrate diet will reduce the fat mobilizing effects of ephedrine. This being the case, I generally recommend a low carb diet to get the most out of ephedrine and caffeine. Keep in mind, however, that over time, your body will not respond so well to ephedrine when on a low carb diet. This should not surprise you considering your metabolic rate (reflecting CNS activity) will drop like a led zeppelin on a low carb diet anyway. So, a periodic carb up is helpful in keeping ephedrine’s thermogenic properties high. A carb up should last no longer than 2 days. I may be helpful to keep fat low during these two days, or if you must eat fat, make sure it is n-3 and/or n-6 fatty acids.
You may have heard the Clenbuterol prevents muscle loss during a diet. This is true. Beta-adrenergic stimulation can preserve muscle protein. If you ask your average bodybuilder they will usually tell you that indeed Clenbuterol saves muscle, but ephedrine won’t. They are wrong, of course. In studies measuring body composition as well as weight loss, ephedrine has shown the ability to prevent lean tissue loss (3). In a small double blind study lasting eight weeks, two groups of obese women were given either 20 mg ephedrine with 200 mg caffeine (E+C) or placebo (P) three times daily. After eight weeks weight loss was not significantly different between the groups, but the E + C group lost 4.5 kg more body fat and 2.8 kg less fat free mass (FFM). That is a difference of more than six pounds in eight weeks. The expected decrease in 24-hour energy expenditure (EE) seen in the P group was 10% at day 1 and 13% at day 56, but was only 7% and 8% in the treated group. The higher EE in the E +C group was entirely covered by fat oxidation.
It’s no secret that Clenbuterol has potent anabolic effects in animals when used in dosages around 4 mg per kg body weight. What does seem to be a secret is that this effect is dependent on Clenbuterol’s long and steady activation of the beta receptors (4). The half-life of Clenbuterol is between 34-35 hours. All of the other beta agonists that have been labeled ineffective at preserving or even building muscle have half-lives much shorter, around only 6 hours. It has been demonstrated however, that when you infuse beta agonists with short half-lives, you can elicit the same anabolic activity (4). The reason is because infusion circumvents the half-life issue all together, providing a steady stream of agonist for the beta-receptors.
So what does all this have to do with ephedrine? Well, ephedrine also has a very short half-life, only about 3-4 hours. Keep in mind that this does not mean that ephedrine levels are high for the full 3-4 hours. In reality, they will peak early and then begin to decline quite rapidly. So if you are taking ephedrine every 4 hours, levels are pretty low for most of that time. What’s the solution? Simple. Take ephedrine at least every 2 hours. You will find in doing so that you don’t get the hills and valleys in your mood either.
NOTE: if you are taking 20 mg ephedrine with 200 mg caffeine every 4 hours, you should half the dose to take it every 2 hours. That way you are still taking the same total amount over the course of the day. You will be surprised at how such a small change can dramatically improve the experience and results of using ephedrine and caffeine.
Side Effects are common when this drug is abused, and if they start occurring the user should lower the dosage or frequency of use.
These are the most frequently seen side effects of ephedrine:
The ECA stack is popular in bodybuilding circles as an appetite suppressor and fat burner. The letter “E” stands for ephedrine 25-50mgs, “C” for caffeine 200-300mgs, and “A” for aspirin 100mgs. Among other factors, the precise dosage will greatly depend on body weight.
In general, users should start out with a low dose and then work their way up. Bodybuilders usually split the dosage into 2-3 parts to be taken during the day. This strategy is employed by both males and females.
The half life of ephedrine is roughly 3-6 hours. Therefore, if the user wants to have the drug in the system the entire day, ephedrine should be dosed 2-3 times per day.
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